MC-Val-Cit-PAB-duocarmycin |
| Katalog-Nr.GC36571 |
MC-Val-Cit-PAB-Duocarmycin ist ein Wirkstoff-Linker-Konjugat fÜr ADC mit starker AntitumoraktivitÄt unter Verwendung von Duocarmycin (einem DNA-Bindungsalkylierungsmittel in der kleinen Furche), das Über den ADC-Linker MC-Val-Cit-PAB verknÜpft ist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055896-98-3
Sample solution is provided at 25 µL, 10mM.
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MC-Val-Cit-PAB-duocarmycin has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-duocarmycin is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
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