Aurora Kinase Inhibitor 3 |
| Katalog-Nr.GC38441 |
A potent inhibitor of Aurora A kinase
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 879127-16-9
Sample solution is provided at 25 µL, 10mM.
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Aurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor 3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket, and several induced structural changes in the active-site compared with other published AIK structures[1].
[1]. Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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