WYE-687 dihydrochloride |
| Katalog-Nr.GC38473 |
WYE-687 Dihydrochlorid ist ein ATP-kompetitiver mTOR-Inhibitor mit einem IC50 von 7 nM. WYE-687-Dihydrochlorid hemmt gleichzeitig die Aktivierung von mTORC1 und mTORC2. WYE-687 hemmt auch PI3Kα und PI3Kγ mit IC50-Werten von 81 nM bzw. 3,11 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1702364-87-1
Sample solution is provided at 25 µL, 10mM.
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WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].
[1]. Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. [2]. Cheng F, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.
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