MEGX (hydrochloride) (Synonyms: Monoethylglycinexylidide, Norlidocaine) |
| Katalog-Nr.GC45508 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7729-94-4
Sample solution is provided at 25 µL, 10mM.
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MEGX is an active metabolite of lidocaine.1 It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.2 Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.1
References
1. Reichel, C., Skodra, T., Nacke, A., et al. The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans. Br. J. Clin. Pharmacol. 46(6), 535-539 (1998).
2. Luostarinen, V., Evers, H., Lyytik•inen, M.T., et al. Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury. Acta Anaesthesiol. Scand. 25(1), 9-11 (1981).
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