Nonapeptide-1 (acetate) (Synonyms: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, MPFRWFKPV-NH2, 153N-6) |
| Katalog-Nr.GC45529 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Nonapeptide-1 is an antagonist of melanocortin receptor 1 (MC1R; Ki = 40 nM in COS-1 cells expressing human receptors).1 It is selective for MC1R over MC3R, MC4R, and MC5R (Kis = 470, 1,340, and 2,400 nM, respectively). Nonapeptide-1 inhibits cAMP accumulation and melanosome dispersion induced by α-melanocyte-stimulating hormone (α-MSH) in melanocytes with IC50 values of 2.5 and 11 nM, respectively.2
References
1. Schi•th, H.B., Muceniece, R., and Wikberg, J.E.S. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997).
2. Jayawickreme, C.K., Quillan, J.M., Graminski, G.F., et al. Discovery and structure-function analysis of α-melanocyte-stimulating hormone antagonists. J. Biol. Chem. 269(47), 29846-29854 (1994).
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