Homo-PROTAC pVHL30 degrader 1 |
| Katalog-Nr.GC65285 |
Homo-PROTAC pVHL30-Degrader 1 ist ein potenter pVHL30-Degrader auf Basis von PROTAC, bestehend aus zwei Liganden von von Hippel-Lindau.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2244684-49-7
Sample solution is provided at 25 µL, 10mM.
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Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.
Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].
[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.
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