JHU 37152 |
| Katalog-Nr.GC50681 |
JHU 37152 ist ein potenter und ins Gehirn eindringender DREADD-Agonist mit EC50-Werten von 5 nM und 0,5 nM für hM3Dq- bzw. hM4Di-DREADDs in HEK-293-Zellen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2369979-67-7
Sample solution is provided at 25 µL, 10mM.
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High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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