Menaquinone 9 (Synonyms: MK-9, Vitamin K2(45)) |
Katalog-Nr.GC44155
One-Click Copy Product Info
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Menaquinon 9 (MK-9) ist ein Vitamin-K2-Analogon, das in verschiedenen Bakterien gefunden wurde, einschließlich E.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 523-39-7
Sample solution is provided at 25 µL, 10mM.
Menaquinone 9 (MK-9) is a vitamin K2 analog found in various bacteria, including Escherichia coli[1, 2]. MK-9 functions as a blood clotting factor and a functional electron-transfer component in nitrate reductase[3]. MK-9 is typically obtained from animal tissues or fermented dairy products such as cheese[4]. High dietary intake of MK-7, MK-8, and MK-9 may help prevent coronary heart disease[5]. Although dietary MK-9 is a precursor to MK-4 in bone tissue, dietary MK-9 supplementation does not affect bone tissue quality or bone mineral density[6].
References:
[1] Crāciun A M, Groenen-van Dooren M, Thijssen H H W, et al. Induction of prothrombin synthesis by K-vitamins compared in vitamin K-deficient and in brodifacoum-treated rats[J]. Biochimica et Biophysica Acta (BBA)-General Subjects, 1998, 1380(1): 75-81.
[2] Koehn J T, Crick D C, Crans D C. Synthesis and characterization of partially and fully saturated menaquinone derivatives[J]. ACS omega, 2018, 3(11): 14889-14901.
[3] Brito F, DeMoss J A, Dubourdieu M. Isolation and identification of menaquinone-9 from purified nitrate reductase of Escherichia coli[J]. Journal of bacteriology, 1995, 177(13): 3728-3735.
[4] Vermeer C, Raes J, Van’t Hoofd C, et al. Menaquinone content of cheese[J]. Nutrients, 2018, 10(4): 446.
[5] Gast G C M, de Roos N M, Sluijs I, et al. A high menaquinone intake reduces the incidence of coronary heart disease[J]. Nutrition, Metabolism and Cardiovascular Diseases, 2009, 19(7): 504-510.
[6] Liu M, Liu C, Cevallos N, et al. Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice[J]. bioRxiv, 2025.
| Cas No. | 523-39-7 | SDF | |
| Überlieferungen | MK-9, Vitamin K2(45) | ||
| Chemical Name | 2-methyl-3-[(2E,6E,10E,14E,18E,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaen-1-yl]-1,4-naphthalenedione | ||
| Canonical SMILES | O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=C(C)C(C2=CC=CC=C21)=O | ||
| Formula | C56H80O2 | M.Wt | 785.2 |
| Löslichkeit | 100mg/mL in chloroform | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2736 mL | 6.3678 mL | 12.7356 mL |
| 5 mM | 254.7 μL | 1.2736 mL | 2.5471 mL |
| 10 mM | 127.4 μL | 636.8 μL | 1.2736 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)