Methylmalonate (Synonyms: Isosuccinic Acid, Methylmalonate, MMA, NSC 25201) |
| Katalog-Nr.GC13670 |
Methylmalonat (Methylmalonat) ist ein Indikator fÜr Vitamin B-12-Mangel bei Krebs.
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Cas No.: 516-05-2
Sample solution is provided at 25 µL, 10mM.
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Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.
Vitamin B-12 is required for Methylmalonate (Methylmalonic acid; MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine. Therefore, Methylmalonate is clearly more specific to vitamin B-12 deficiency compared to HC[1].
References:
[1]. Vashi P, et al. Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer. PLoS One. 2016 Jan 25;11(1):e0147843.
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