MK6-83 |
| Katalog-Nr.GC18564 |
MK6-83 ist ein neuer Kandidat fÜr einen Agonisten von TRPML1 mit verbesserter Wirksamkeit und Potenz.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1062271-24-2
Sample solution is provided at 25 µL, 10mM.
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MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts. It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.
Review for MK6-83
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
Review for MK6-83
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