NADP+ (Synonyms: Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN) |
Katalog-Nr.GC44307
One-Click Copy Product Info
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NADP+ ist die oxidierte Form des Elektronendonors Nicotinamidadenindinukleotidphosphat.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53-59-8
Sample solution is provided at 25 µL, 10mM.
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NADP+ ist die oxidierte Form des Elektronendonors Nicotinamidadenindinukleotidphosphat. NADP+ ist zusammen mit seiner reduzierten Form, dem reduzierten NADPH, an der Aufrechterhaltung des Redox-Gleichgewichts sowie der Unterstützung der Biosynthese von Fettsäuren und Nukleinsäuren beteiligt [1].
NADP+, ein strukturelles Analogon von NAD+, wird durch die Übertragung einer Phosphatgruppe von ATP auf die 2′-Hydroxygruppe des Adenosin-Ribose-Rests von NAD+ synthetisiert. Diese Reaktion wird durch NADKs katalysiert [2]. NADP+ fungiert als Kofaktor in verschiedenen biologischen Reaktionen [3]. NADP+/NADPH spielt eine wichtige Rolle bei der Regulierung des zellulären Redox-Zustands, des Energiestoffwechsels, der mitochondrialen Funktion, der Genexpression und der Signalwege. NADP+/NADPH sind essentiell für die Aufrechterhaltung einer Vielzahl biologischer Prozesse [3,4,5].
References:
[1]. Yang, Yue, and Anthony A. Sauve. "NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864.12 (2016): 1787-1800.
[2]. Ying, Weihai. "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences." Antioxidants & redox signaling 10.2 (2008): 179-206.
[3]. Jackson J B. A review of the binding-change mechanism for proton-translocating transhydrogenase[J]. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012, 1817(10): 1839-1846.
[4]. CantÓ, Carles, and Johan Auwerx. "NAD+ as a signaling molecule modulating metabolism." Cold Spring Harbor symposia on quantitative biology. Vol. 76. Cold Spring Harbor Laboratory Press, 2011.
[5]. CantÓ, Carles, Keir J. Menzies, and Johan Auwerx. "NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus." Cell metabolism 22.1 (2015): 31-53.
| Cas No. | 53-59-8 | SDF | |
| Überlieferungen | Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN | ||
| Chemical Name | adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt | ||
| Canonical SMILES | O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)(O)=O | ||
| Formula | C21H28N7O17P3 | M.Wt | 743.4 |
| Löslichkeit | Soluble in PBS, PH7.2, 10mg/mL | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3452 mL | 6.7259 mL | 13.4517 mL |
| 5 mM | 269 μL | 1.3452 mL | 2.6903 mL |
| 10 mM | 134.5 μL | 672.6 μL | 1.3452 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)