NMDAR antagonist 1 |
| Katalog-Nr.GC34352 |
NMDAR-Antagonist 1 ist ein potenter und oral bioverfÜgbarer NR2B-selektiver NMDAR-Antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2220162-06-9
Sample solution is provided at 25 µL, 10mM.
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NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].
NMDAR antagonist 1 (Compound 5q) exhibits excellent neuroprotective activity[1]. NMDAR antagonist 1 can attenuate Ca2+ influx induced by NMDA[1].NMDAR antagonist 1 can suppress the NR2B up-regulation and increase p-ERK1/2 expression[1].NMDAR antagonist 1 inhibits SH-SY5Y cells with cell viabilities of 75.8%, 80.0%, 84.4%, and 78.6% at 0.1 µM 1 µM 10 µM 100 µM, respectively[1].
[1]. Zhang L, et al. Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. Eur J Med Chem. 2018 May 10;151:27-38.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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