NV03 |
| Katalog-Nr.GC64772 |
NV03 ist ein potenter und selektiver Antagonist der UHRF1 (Ubiquitin-Ähnlich mit PHD- und RING-Finger-DomÄnen 1)-H3K9me3-Interaktion durch Bindung an die UHRF1-Tandem-Tudor-DomÄne mit einem Kd von 2,4 μM. NV03 hat AntikrebsaktivitÄt.
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Cas No.: 2448341-58-8
Sample solution is provided at 25 µL, 10mM.
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NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity[1].
[1]. Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23(9):930-940.
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