Oleoyl-Coenzyme A (sodium salt) (Synonyms: Oleoyl (cis-9-C18:1)-CoA, Oleoyl-CoA)

Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid and CoA . It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.^1,2,3 Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter in E. coli (K_i = 0.005 &#181M).⁴ Oleoyl-CoA (1 &#181M) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel K_ir6.2 in Xenopus oocytes.⁵

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