Pomalidomide-PEG2-azide |
Katalog-Nr.GC61617 |
Pomalidomid-PEG2-Azid ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den Pomalidomid-basierten Cereblon-Liganden und den 2-Einheiten-PEG-Linker enthÄlt, die in der PROTAC-Technologie verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2267306-14-7
Sample solution is provided at 25 µL, 10mM.
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *