Seclidemstat (SP-2577) (Synonyms: SP-2577) |
| Katalog-Nr.GC32820 |
Seclidemstat (SP-2577) ist ein potenter, nicht kompetitiver und reversibler KDM1A (LSD1)-Hemmer (Ki=31 nM, IC50=13 nM). Seclidemstat (SP-2577) fÖrdert die Antitumor-ImmunitÄt bei Eierstockkrebs mit Switch/Sucrose Nonfermentable (SWI/SNF)-Mutation und hemmt die Virusproduktion, die virale DNA-Replikation und die spÄte Genexpression. Secldemstat (SP-2577) kann fÜr die Erforschung des Ewing-Sarkoms verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1423715-37-0
Sample solution is provided at 25 µL, 10mM.
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Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.
[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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