Seselin |
Katalog-Nr.GC46221
One-Click Copy Product Info
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An angular pyranocoumarin with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 523-59-1
Sample solution is provided at 25 µL, 10mM.
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Seselin is an angular pyranocoumarin that has been found in M. semecarpifolia and has diverse biological activities.1,2,3,4 It is cytotoxic to P388 and HT-29 cells in vitro (EC50s = 8.66 and 9.94 μg/ml).1 Seselin (0.5, 4.5, and 40.5 mg/kg) reduces acetic acid-induced writhing in mice.2 It also reduces paw licking in the first and second phases of the formalin test in mice when administered 30 minutes prior to formalin. Seselin (3, 10, and 30 mg/kg) decreases serum levels of IL-1β, IL-6, and TNF-α in a mouse model of sepsis induced by cecal ligation and puncture and increases survival when administered at a dose of 30 mg/kg.3 It reduces ear edema induced by phorbol 12-myristate 13-acetate in mice (ED45 = 0.25 mg/ear).4
|1. Chou, H.-C., Chen, J.-J., Duh, C.-Y., et al. Cytotoxic and anti-platelet aggregation constituents from the root wood of Melicope semecarpifolia. Planta Med. 71(11), 1078-1081 (2005).|2. Lima, V., Silva, C.B., Mafezoli, J., et al. Antinociceptive activity of the pyranocoumarin seselin in mice. Fitoterapia 77(7-8), 574-578 (2006).|3. Feng, L., Sun, Y., Song, P., et al. Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. Br. J. Pharmacol. 176(2), 317-333 (2019).|4. GarcÍa-ArgÁez, A.N., RamÍrez Apan, T.O., Parra Delgado, H., et al. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med. 66(3), 279-281 (2000).
| Cas No. | 523-59-1 | SDF | |
| Canonical SMILES | O=C1C=CC(C=CC2=C3C=CC(C)(C)O2)=C3O1 | ||
| Formula | C14H12O3 | M.Wt | 228.2 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3821 mL | 21.9106 mL | 43.8212 mL |
| 5 mM | 876.4 μL | 4.3821 mL | 8.7642 mL |
| 10 mM | 438.2 μL | 2.1911 mL | 4.3821 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)