TAN 452 |
| Katalog-Nr.GC50558 |
TAN 452 ist ein oral aktiver, selektiver peripher wirkender δ-Opioidrezeptor (DOR)-Antagonist mit einem Ki von 0,47 nM und einem Kb von 0,21 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 892039-23-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective peripherally acting δ opioid antagonist; Ki values are 0.47, 5.31 and 36.56 nM at hDOR, hKOR, and hMOR, respectively. Kb values are 0.21, 7.18 and 9.43 nM, respectively. Attenuates morphine-induced side effects in vivo. Antianalgesic.
Lattanzi et al (2018) In vitro and in vivo pharmacological activities of 14-O-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice. Front.Pharmacol. 9 10.3389/fphar.2018.0 PMID:30233377
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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