Tazarotenic Acid (Synonyms: AGN 190299) |
| Katalog-Nr.GC45001 |
TazarotensÄure ist der Metabolit von Tazaroten.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 118292-41-4
Sample solution is provided at 25 µL, 10mM.
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Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM. Tazarotenic acid selectively binds retinoic acid receptors (RAR-β and RAR-γ) in vitro. It has a relatively short elimination half-life of one to two hours and is metabolized by cytochrome P450 (CYP) isoforms CYP2C8, CYP26A1, and CYP26B1.
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