Thalidomide-NH-PEG7 |
Katalog-Nr.GC67500 |
Thalidomide-NH-PEG7 ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat für ADC. Thalidomid-NH-PEG7 kann über einen Linker mit dem Proteinliganden verbunden werden, um PROTAC iRucaparib-AP6, einen hochspezifischen PARP1-Abbaustoff, zu bilden.
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Cas No.: 2641838-98-2
Sample solution is provided at 25 µL, 10mM.
Thalidomide-NH-PEG7 is a synthesized E3 ligase ligand-linker conjugate for ADC. Thalidomide-NH-PEG7 can be connected to the ligand for protein by a linker to form PROTAC iRucaparib-AP6, a highly specific PARP1 degrader[1].
[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.Nat Chem Biol. 2019 Dec;15(12):1223-1231.
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