TT-232 (trifluoroacetate salt) |
| Katalog-Nr.GC52412 |
A synthetic peptide derivative of somatostatin
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
TT-232 is a synthetic peptide derivative of somatostatin.1 It binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM). TT-232 (30 and 60 µg/ml) inhibits the proliferation of P388 murine and HL-60 human leukemia cells.2 In vivo, TT-232 (3-12 µg/animal per day) reduces tumor volume in an HL-60 mouse xenograft model. It inhibits intradermal neutrophil accumulation and ear edema induced by capsaicin in rats.3 TT-232 (5-20 µg/kg, i.p.) inhibits mechano-nociceptive hyperalgesia in rats.
1.Simon, Á., KÉri, G., and Kardos, J.Comparison of the binding modes of TT-232 in somatostatin receptors type 1 and 4Theochem.816(1-3)73-76(2007) 2.Tejeda, M., Gaal, D., Csuka, O., et al.Growth inhibitory effect of the somatostatin structural derivative (TT-232) on leukemia modelsAnticancer Res.25(1A)325-330(2005) 3.PintÉr, E., Helyes, Z., NÉmeth, J., et al.Pharmacological characterisation of the somatostatin analogue TT-232: Effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesiaNaunyn Schmiedebergs Arch. Pharmacol.366(2)142-150(2002)
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *