1-Ethynylnaphthalene |
| カタログ番号GC33073 |
1-エチニルナフタレンは、シトクロム P450 1B1 の選択的阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15727-65-8
Sample solution is provided at 25 µL, 10mM.
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1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1.
1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1].
[1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4.
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