(±)-Cloprostenol sodium salt (Synonyms: (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol) |
| カタログ番号GC16838 |
(±)-クロプロステノール ナトリウム塩 (ICI 80996 ナトリウム塩) は、強力な合成プロスタグランジン アナログであり、黄体溶解剤として作用し、PGF2α 受容体アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55028-72-3
Sample solution is provided at 25 µL, 10mM.
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Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent[1], and is a PGF2α receptor agonist[2].
Cloprostenol is a PGF2α receptor agonist[2].Cloprostenol (0.1 μM) counteracts the adipogenic effects of statil, on both intracellular lipid accumulation and expression of transcripts for proadipogenic factors C/EBPα and PPARγ after treatment for 6 days[2].
Cloprostenol sodium salt (25 μg) decreases plasma progesterone in pregnant rats[1].
References:
[1]. Salazar H, et al. Luteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. Biol Reprod. 1976 May;14(4):458-72.
[2]. Pastel E, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84.
| Cas No. | 55028-72-3 | SDF | |
| 同義語 | (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol | ||
| Chemical Name | sodium (E)-7-((1R,2R,3S,5R)-2-((R,Z)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate | ||
| Canonical SMILES | ClC1=CC(OC[C@@H](/C=C\[C@@H]([C@H]2O)[C@@H](C/C=C/CCCC([O-])=O)[C@@H](C2)O)O)=CC=C1.[Na+] | ||
| Formula | C22H28ClNaO6 | M.Wt | 446.9 |
| 溶解度 | DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2376 mL | 11.1882 mL | 22.3764 mL |
| 5 mM | 0.4475 mL | 2.2376 mL | 4.4753 mL |
| 10 mM | 0.2238 mL | 1.1188 mL | 2.2376 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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