(±)-Cloprostenol sodium salt (Synonyms: (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol) |
| カタログ番号GC16838 |
(±)-クロプロステノール ナトリウム塩 (ICI 80996 ナトリウム塩) は、強力な合成プロスタグランジン アナログであり、黄体溶解剤として作用し、PGF2α 受容体アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55028-72-3
Sample solution is provided at 25 µL, 10mM.
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Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent[1], and is a PGF2α receptor agonist[2].
Cloprostenol is a PGF2α receptor agonist[2].Cloprostenol (0.1 μM) counteracts the adipogenic effects of statil, on both intracellular lipid accumulation and expression of transcripts for proadipogenic factors C/EBPα and PPARγ after treatment for 6 days[2].
Cloprostenol sodium salt (25 μg) decreases plasma progesterone in pregnant rats[1].
References:
[1]. Salazar H, et al. Luteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. Biol Reprod. 1976 May;14(4):458-72.
[2]. Pastel E, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84.
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