9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (Synonyms: αESA ethyl ester, Ethyl αeleostearate) |
| カタログ番号GC40785 |
9(Z),11(E),13(E)-オクタデカトリエン酸エチルエステル（α-ESA）は、植物種子油に一般的に存在する共役ポリ不飽和脂肪酸です。
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Cas No.: 42021-86-3
Sample solution is provided at 25 µL, 10mM.
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9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.
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