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Amarogentin

カタログ番号GC42776

アマロゲンチンは、主にセンブリとリンドウの根から抽出されるセコイリドイド配糖体です。

Products are for research use only. Not for human use. We do not sell to patients.

Amarogentin 化学構造

Cas No.: 21018-84-8

サイズ 価格 在庫数 個数
1mg
$33.00
在庫あり
5mg
$83.00
在庫あり
10mg
$139.00
在庫あり
25mg
$278.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

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  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis when used at a concentration of 50 µM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.

Chemical Properties

Cas No. 21018-84-8 SDF
Canonical SMILES O=C1OCC[C@]2([H])C1=CO[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3OC(C4=C(C5=CC=CC(O)=C5)C=C(O)C=C4O)=O)[C@@H]2C=C
Formula C29H30O13 M.Wt 586.5
溶解度 DMSO: 100 mg/ml,PBS (pH 7.2): 0.1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.705 mL 8.5251 mL 17.0503 mL
5 mM 0.341 mL 1.705 mL 3.4101 mL
10 mM 0.1705 mL 0.8525 mL 1.705 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for Amarogentin

Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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