C2 Phytoceramide (t18:0/2:0) (Synonyms: N-Acetyl Phytosphingosine, C2:0 Phytoceramide, Cer(t18:0/2:0), Ceramide (t18:0/2:0), NAPS) |
| カタログ番号GC43065 |
C2フィトセラミドは、懸濁した好中球細胞において、フォルミルペプチド誘導性酸化物放出を抑制する生体活性半合成スフィンゴ脂質であり、IC50値は0.38μMです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 µM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 µM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 µM, and induces internucleosomal DNA fragmentation. In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro.
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