Elubrixin tosylate (Synonyms: SB-656933 tosylate) |
| カタログ番号GC60804 |
エルブリキシン トシレート (SB-656933 トシレート) は、強力、選択的、競合的、可逆的、経口的に活性な CXCR2 アンタゴニストであり、IL-8 受容体アンタゴニストでもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 960495-43-6
Sample solution is provided at 25 µL, 10mM.
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Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].
Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion[1].
[1]. Mozaffari S, et al. Inflammatory bowel disease therapies discontinued between 2009 and 2014. Expert Opin Investig Drugs. 2015;24(7):949-56. [2]. Lazaar AL, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72(2):282-93. [3]. Nicholson GC, et al. A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther. 2007;20(1):52-9.
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