CAY10698 |
| カタログ番号GC43194 |
CAY10698 (化合物 1) は、5.1 μM の IC50 を持つ 12-リポキシゲナーゼ (12-LOX) の強力かつ選択的な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 684236-01-9
Sample solution is provided at 25 µL, 10mM.
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Platelet-type 12-lipoxygenase catalyzes the formation of 12-HpETE from arachidonic acid . It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM. The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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