GA-017 |
| カタログ番号GC65116 |
GA-017 は、強力かつ選択的な LATS1 および LATS2 (大型腫瘍抑制キナーゼ 1/2) 阻害剤であり、IC50 値はそれぞれ 4.10 および 3.92 nM です。 GA-017 は細胞増殖の活性化剤です。 GA-017 は、YAP/TAZ の活性化と核移行を促進します。 GA-017 は、3D 培養条件下で細胞増殖を促進します。 GA-017 は、マウス腸オルガノイドの ex vivo 形成を促進します。
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Cas No.: 2351906-74-4
Sample solution is provided at 25 µL, 10mM.
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].
GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1].
[1]. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779.
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