dTRIM24 |
| カタログ番号GC35904 |
dTRIM24 は、PROTAC に基づく TRIM24 の選択的二機能分解剤であり、von Hippel-Lindau および TRIM24 のリガンドで構成されています。
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Cas No.: 2170695-14-2
Sample solution is provided at 25 µL, 10mM.
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dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC. TRIM24[2].
dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2].
[1]. Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14(4):405-412.
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