GLP-26 |
| カタログ番号GC38785 |
GLP-26 は HBV キャプシド アセンブリ モジュレーター (CAM) であり、Hep AD38 システムで HBV DNA 複製を阻害し (IC50=3 nM)、cccDNA を 1 μM で >90% 減少させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2133017-36-2
Sample solution is provided at 25 µL, 10mM.
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GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].
GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells
[1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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