Glucagon receptor antagonists-4 (Synonyms: GCGR Antagonist IV) |
| カタログ番号GC19170 |
グルカゴン受容体アンタゴニスト-4 は、非常に強力な非ペプチドの経口活性グルカゴン受容体アンタゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1393124-08-7
Sample solution is provided at 25 µL, 10mM.
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Glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. It displays low in vivo clearance and excellent oral bioavailability in both rats and dogs.
References:
[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.
[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.
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