GNE 5729 |
| カタログ番号GC31076 |
ＧＮＥ ５７２９は、ＧｌｕＮ２Ａについて３７ｎＭ、ＧｌｕＮ２ＣおよびＧｌｕＮ２Ｄについてそれぞれ４．７および９．５μＭのＥＣ５０を有する、脳透過性のＮＭＤＡＲの正のアロステリック調節因子である。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2026635-66-3
Sample solution is provided at 25 µL, 10mM.
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GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1].
[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
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