hSMG-1 inhibitor 11j |
| カタログ番号GC61925 |
ピリミジン誘導体であるｈＳＭＧ－１阻害剤１１ｊは、ｈＳＭＧ－１の強力かつ選択的な阻害剤であり、ＩＣ５０は０．１１ｎＭである。 hSMG-1 阻害剤 11j は、mTOR (IC50=50 nM)、PI3Kα/γ (IC50=92/60 nM)、および CDK1/CDK2 (IC50=32/7.1 μM) よりも hSMG-1 に対して >455 倍の選択性を示します。 hSMG-1 阻害剤 11j は、がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1402452-15-6
Sample solution is provided at 25 µL, 10mM.
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hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 µM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].
hSMG-1 inhibitor 11j (0.3-3 µM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 µM, and eliminates it at 1 µM in MDA 361 cells[1].hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1].
References:
[1]. Gopalsamy A, et, al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.
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