Monohydroxy Melphalan (hydrochloride) (Synonyms: Hydroxymelphalan) |
| カタログ番号GC44243 |
モノヒドロキシメルファランは、DNAアルキル化剤であり、メルファランの分解生成物です。
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Sample solution is provided at 25 µL, 10mM.
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Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan . Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma. It increases the level of DNA adducts in ML-1 myeloblastic leukemia cells in a concentration-dependent manner and induces cytotoxicity with an IC50 value of 28.1 μg/ml.
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