Naspm trihydrochloride (Synonyms: 1-Naphthylacetyl spermine) |
| カタログ番号GC13349 |
Naspm 三塩酸塩 (1-ナフチルアセチルスペルミン三塩酸塩) は、ジョロクモ毒素の合成類似体であり、カルシウム透過性 AMPA (CP-AMPA) 受容体アンタゴニストです。
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Cas No.: 1049731-36-3
Sample solution is provided at 25 µL, 10mM.
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Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].
References:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.
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