PROTAC BRD4 Degrader-5 |
| カタログ番号GC61212 |
PROTAC BRD4 Degrader-5 は、von Hippel-Lindau と BRD4 のリガンドによって結合された PROTAC です。 PROTAC BRD4 Degrader-5 は、HER2 陽性および陰性の乳がん細胞株で BRD4 を強力に分解できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2409538-70-9
Sample solution is provided at 25 µL, 10mM.
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PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1]. Western Blot Analysis[1] Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells
[1]. Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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