TL 13-112 |
| Katalog-Nr.GC50561 |
TL 13-112 ist ein potenter und selektiver ALK-PROTAC-Abbauer und hemmt die ALK-Aktivität mit einem IC50-Wert von 0,14 nM. TL 13–112 veranlasst auch den Abbau zusätzlicher Kinasen, einschließlich Aurora A, FER, PTK2 und RPS6KA1 mit IC50-Werten von 8550 nM, 42,4 nM, 25,4 nM bzw. 677 nM. TL 13-112 besteht aus der Konjugation von Ceritinib und dem Cereblon-Liganden von Pomalidomid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229037-19-6
Sample solution is provided at 25 µL, 10mM.
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Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h. Negative control TL 13-110 also available.
Powell et al (2019) Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 61 4249 PMID:29660984
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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