Calmidazolium chloride (Synonyms: R 24571) |
| Catalog No.GC14326 |
염화 칼미다졸륨(R 24571)은 칼모듈린(CaMK) 길항제로서, 각각 0.15 및 0.35μM의 IC50으로 ATPase를 수송하는 CaM 의존성 포스포디에스테라제 및 칼모듈린 유도 적혈구 활성화를 길항합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57265-65-3
Sample solution is provided at 25 µL, 10mM.
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Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively).[1] Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 µM, respectively).[1] It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 µM).[2],[3]
Reference:
[1]. Gietzen, K. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochemistry Journal 216(3), 611-616 (1983).
[2]. Harper, J.L., and Daly, J.W. Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochemical Pharmacology 60(3), 317-324 (2000).
[3]. Peppiatt, C.M., Holmes, A.M., Seo, J.T., et al. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochemistry Journal 381(3), 929-939 (2004).
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