Calmidazolium chloride (Synonyms: R 24571) |
| Catalog No.GC14326 |
Calmodulin antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57265-65-3
Sample solution is provided at 25 µL, 10mM.
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Calmidazolium (chloride) is an inhibitor of calmodulin (CaM), inhibiting CaM-dependent phosphodiesterase and CaM-induced activation of erythrocyte calcium-transporting ATPase (IC50 = 0.15 and 0.35 µM, respectively).[1] Calmidazolium also inhibits an array of calcium-transporting ATPases, including those from heart and skeletal muscle (IC50 = 2.1 and 2.9 µM, respectively).[1] It also induces the influx of extracellular calcium through store-operated calcium channels (EC50 = 3 µM).[2],[3]
Reference:
[1]. Gietzen, K. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochemistry Journal 216(3), 611-616 (1983).
[2]. Harper, J.L., and Daly, J.W. Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochemical Pharmacology 60(3), 317-324 (2000).
[3]. Peppiatt, C.M., Holmes, A.M., Seo, J.T., et al. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochemistry Journal 381(3), 929-939 (2004).
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