GSK199 (hydrochloride) |
| Catalog No.GC43789 |
GSK199(염산염)는 칼슘이 없을 때 IC50이 200nM인 가역적이고 선택적 PAD4 억제제입니다.
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Cas No.: 1549811-53-1
Sample solution is provided at 25 µL, 10mM.
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Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3.It is less potent than the related PAD4 inhibitor GSK484 , which demonstrates an IC50 value of 50 nM. GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.
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