MSG 606 |
Catalog No.GC50303
One-Click Copy Product Info
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MSG 606은 human melanocortin 1 receptor (hMC1R)에 대한 강력한 항작용 활동과 수용체 선택성을 가지고 있다(IC50 = 17 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416983-77-1
Sample solution is provided at 25 µL, 10mM.
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MSG 606은 human melanocortin 1 receptor (hMC1R)에 대한 강력한 항작용 활동과 수용체 선택성을 가지고 있다(IC50 = 17 nM).
MSG-606은 피부암 진단에서 특히 멜라놈세포를 특이적으로 타겟팅하기 위한 뛰어난 탐지제이다. MSG-606은 멜라놈 세포에 대한 항작용제로 작용합니다. MSG-606은 인간 멜라놈 세포(A375)에 대한 결합 및 cAMP 활동을 통해 IC50 96 nM [1]을 달성한다.
MSG-606(1nmol/µl, 6µl)은 subarachnoid hemorrhage (SAH )모델에서 BMS-470539/MC1R 시스템의 신경 보호 작용을 막했다[2].
References:
[1]:Cai M, Stankova M, Muthu D, et al. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells[J]. Biochemistry, 2013, 52(4): 752-764.
[2]:Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x
| 동물 실험 [2]: | |
동물 모형 | 수컷 Sprague-Dawley (SD) 쥐 |
제조 방법 | 쥐는 다음과 같이 5개 그룹으로 무작위로 나뉩니다: 가짜 수술 그룹, SAH + 차량 1(10 µl 무기생 염산염, i.n), SAH + BMS-470539 (160 µg/kg, 10 µl), SAH + BMS-470539 + 차량 2(6 µl 무기생 염산염, i.c.v), 그리고 SAH + BMS-470539 + MSG-606(1 nmol/µl, 6 µl). MSG-606은 i.c.v 경로를 통하여 SAH 1시간 전에 투여되었습니다. SAH 이후 24시간에 신경학적 테스트가 실시되었습니다. 동측/왼쪽 대뇌 피질은 웨스턴 블로팅을 위해 채취되었습니다. |
제형 | 1 nmol/µl, 6 µl, i.c.v |
응용 분야 | MSG-606은 MC1R을 억제하여 SAH + BMS-470539 + 차량 2 그룹과 비교할 때 BMS-470539의 항염증 효과를 현저하게 상쇄시켰습니다. |
참고문헌: [1]: Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x | |
| Cas No. | 1416983-77-1 | SDF | |
| Canonical SMILES | NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1 | ||
| Formula | C62H82N20O13S | M.Wt | 1347.51 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 742.1 μL | 3.7105 mL | 7.4211 mL |
| 5 mM | 148.4 μL | 742.1 μL | 1.4842 mL |
| 10 mM | 74.2 μL | 371.1 μL | 742.1 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)