MSG 606 |
Katalog-Nr.GC50303
One-Click Copy Product Info
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MSG 606 hat eine starke antagonistische Aktivität und Rezeptorselektivität für den menschlichen Melanocortin-1-Rezeptor (hMC1R) (IC50 = 17 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416983-77-1
Sample solution is provided at 25 µL, 10mM.
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MSG 606 hat eine starke antagonistische Aktivität und Rezeptorselektivität für den menschlichen Melanocortin-1-Rezeptor (hMC1R) (IC50 = 17 nM) [1].
MSG-606 ist eine ausgezeichnete Sonde zur gezielten Ansprache von Melanomzellen für die Diagnose von Hautkrebs. MSG-606 wirkt als Antagonist gegen die Melanomzellen. Bindungs- und cAMP-Aktivitäten von MSG-606 gegen menschliche Melanomzellen (A375) mit einem IC50 von 96 nM [1].
MSG-606 (1 nmol/µl, 6 µl) hob die neuroprotektiven Effekte des BMS-470539/MC1R-Systems in einem Subarachnoidalblutungsmodell (SAH) auf [2].
References:
[1]:Cai M, Stankova M, Muthu D, et al. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells[J]. Biochemistry, 2013, 52(4): 752-764.
[2]:Xu, W., Mo, J., Ocak, U. et al. Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats. Neurotherapeutics 17, 294-308 (2020). https://doi.org/10.1007/s13311-019-00772-x
| Tierversuch [1]: | |
Tiermodelle | Männliche Sprague-Dawley (SD)-Ratten |
Vorbereitungsmethode | Die Ratten wurden nach dem Zufallsprinzip in fünf Gruppen aufgeteilt: Scheinbehandlung, SAH + Vehikel(10 µl sterile Kochsalzlösung, i.n), SAH + BMS-470539 (160 µg/kg, 10 µl), SAH + BMS-470539 + Vehikel 2 (6 µl sterile Kochsalzlösung, i.c.v), und SAH + BMS-470539 + MSG-606 (1 nmol/µl, 6 µl). MSG-606 wurde eine Stunde vor der SAH intravenös verabreicht. Neurologische Untersuchungen wurden 24 Stunden nach der SAH durchgeführt. Proben aus dem ipsilateralen/linken zerebralen Kortex wurden für den Western Blot entnommen. |
Dosierungsform | 1 nmol/µl, 6 µl, i.c.v |
Anwendungen | Die Hemmung von MC1R mit MSG-606 hob die entzündungshemmenden Wirkungen von BMS-470539 im Vergleich zur Gruppe SAH+ BMS-470539 + Vehikel 2 erheblich auf |
References: | |
| Cas No. | 1416983-77-1 | SDF | |
| Canonical SMILES | NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1 | ||
| Formula | C62H82N20O13S | M.Wt | 1347.51 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 742.1 μL | 3.7105 mL | 7.4211 mL |
| 5 mM | 148.4 μL | 742.1 μL | 1.4842 mL |
| 10 mM | 74.2 μL | 371.1 μL | 742.1 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)