PAO-Nap |
| Catalog No.GC61552 |
PAO-Nap은 링커로 아미노카프로산을 사용하여 나프탈이미드 형광단에 부착된 변형된 PAO입니다. PAO는 thioredoxin reductase를 선택적으로 표적화하여 HL-60 세포에서 산화 스트레스 매개 세포자멸사를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1613402-20-2
Sample solution is provided at 25 µL, 10mM.
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PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].
PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].
[1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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