PHTPP |
| Catalog No.GC11863 |
PHTPP는 선택적 에스트로겐 수용체 β(ERβ) 길항제로 ERα에 비해 36배 선택성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 805239-56-9
Sample solution is provided at 25 µL, 10mM.
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PHTPP is a selective ERβ antagonist.
PHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (pIgf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression[2].
References:
[1]. Compton DR, et al. Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. J Med Chem. 2004 Nov 18;47(24):5872-93.
[2]. Ogo Y, et al. IGF-1 gene expression is differentially regulated by estrogen receptors α and β in mouse endometrial stromal cells and ovarian granulosa cells. J Reprod Dev. 2014;60(3):216-23. Epub 2014 Mar 25.
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