PROTAC BET degrader-2 |
| Catalog No.GC32980 |
PROTAC BET 분해기-2는 RS4;11 세포에서 세포 성장 억제에서 IC50 값이 9.6nM인 Cereblon 및 BET에 대한 리간드로 연결되어 종양 퇴행을 달성할 수 있는 PROTAC입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093388-33-9
Sample solution is provided at 25 µL, 10mM.
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PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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