PROTAC BET degrader-2 |
| カタログ番号GC32980 |
PROTAC BET degrader-2 は、Cereblon および BET のリガンドによって接続された PROTAC であり、RS4;11 細胞の細胞増殖阻害において 9.6 nM の IC50 値を持ち、腫瘍退縮を達成することができます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2093388-33-9
Sample solution is provided at 25 µL, 10mM.
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PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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