Seclidemstat (SP-2577) (Synonyms: SP-2577) |
| Catalog No.GC32820 |
Seclidemstat(SP-2577)는 강력한 비경쟁적이고 가역적인 KDM1A(LSD1) 억제제(Ki=31nM, IC50=13nM)입니다. Seclidemstat(SP-2577)은 스위치/자당 비발효성(SWI/SNF) 복합 돌연변이 난소암에서 항종양 면역을 촉진할 뿐만 아니라 바이러스 생성, 바이러스 DNA 복제 및 후기 유전자 발현을 억제합니다. Seclidemstat(SP-2577)은 유잉 육종 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1423715-37-0
Sample solution is provided at 25 µL, 10mM.
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Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.
[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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