Home>>Signaling Pathways>> Chromatin/Epigenetics>> Histone Demethylases>>Seclidemstat (SP-2577)
Seclidemstat (SP-2577) Catalog No.GC32820

Size Price Stock Qty
10mM*1mLinDMSO
$179.00
In stock
1mg
$74.00
In stock
5mg
$181.00
In stock
10mg
$287.00
In stock
25mg
$575.00
In stock
50mg
$881.00
In stock
100mg
$1,391.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Chemical Properties

Cas No. 1423715-37-0 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCN(C)CC3)=O)=C2
Formula C20H23ClN4O4S M.Wt 450.94
Solubility DMSO : 100 mg/mL (221.76 mM);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.

Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.

[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1