Seclidemstat (SP-2577) (Synonyms: SP-2577) |
| カタログ番号GC32820 |
Seclidemstat (SP-2577) は、強力な非競合的で可逆的な KDM1A (LSD1) 阻害剤です (Ki=31 nM、IC50=13 nM)。 Seclidemstat (SP-2577) は、スイッチ/スクロース非発酵性 (SWI/SNF) 複合体変異卵巣癌における抗腫瘍免疫を促進し、ウイルス産生、ウイルス DNA 複製、後期遺伝子発現を阻害します。セクリデムスタット (SP-2577) は、ユーイング肉腫の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1423715-37-0
Sample solution is provided at 25 µL, 10mM.
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Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.
Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.
[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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